1.Product Description

Intermediate 1 code name	NB-8(S,S)	Intermediate 1 English name	(S)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
Intermediate 1 CAS	1315508-96-3	Intermediate 1 structural formula
Intermediate 2 code name	NB-8(R,S)	Intermediate 2 English name	(R)-2-chloro-1-((S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
Intermediate 2 CAS	1315508-95-2	Intermediate 2 structural formula
Intermediate 3 code name	NB-8(R,R)	Intermediate 3 English name	(R)-2-chloro-1-((R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
Intermediate 3 CAS	1315508-94-1	Intermediate 3 structural formula
Intermediate 4 code name	NB-8(S,R)	Intermediate 4 English name	(S)-2-chloro-1-((R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
Intermediate 4 CAS	1315508-93-0	Intermediate 4 structural formula
level	Chemical grade	appearance	White solid
Package	25 kg/barrel	Shelf life	2 years
The purity	≥99%	Store condition	Store in a cool, dry and well-ventilated place

The Nebivolol intermediate has two chiral intermediates, it has four enantiomers. Nebivolol is a selective β1 adrenergic receptor antagonist with vasodilatatory activity and no endogenous sensory activity. It is used in the treatment of patients with mild to moderate hypertension, as well as in the treatment of angina pectoris and congestive heart failure.

The company uses keto reductase, the use of synzyme catalytic method to produce nebilol intermediates, products with green, environmental protection, high chiral purity.

                                                                                                   产品结构式

2.Naturalness test report and COA

3.Product Application:

It can be used as medicine intermediate and so on.